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The two kinds of CDs enhance the aqueous solubility of Res. As shown in Fig. 2, the phase-solubility diagrams of Res with β-CD or HP-CD show a linear relationship between the amount of Res solubilised and the concentration of CDs in solution (A L type diagram). According to the theory of Higuchi and Connors (1965), this may be attributed …Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution ...phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.AAPS PharmaSciTech 2005;6:464–72. 18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8. 20.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry ResearchGate | Find and share researchThe phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...In the phase-solubility diagram, the slope was lower than the unit, and the inclusion ratio of BA–β-CD was 1:1. The apparent stability constant (K 1:1) obtained from the Higuchi–Connors formula was 1.3094 × 10 3 mol −1, which showed the existence of favourable interactions. A larger K 1:1 value corresponded to a higher BA solubility ...The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending. 18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8.All the phase-solubility diagrams were of type A except the diagrams of hydrocortisone in γCD and 80/20 γCD/HPγCD solutions were of B S-type according to the Higuchi-Connor classification system. 22 The slopes of the initial linear sections of the diagrams were determined and both the apparent stability constants (K 1:1) and the …Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal Chem Instrum 4: 117 – 212. ICH Q6A Test procedures and acceptance criteria for newPhase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for 24 h with ...Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ...Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …After equilibrium was attained, the suspensions were filtered through 0.45 µm cellulose membrane filter, the filtrates diluted with the mobile phase and analyzed by HPLC. The apparent complexation constants for drug/cyclodextrin complexes (K 1:1) were determined according to the phase-solubility method of Higuchi and Connors.2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels …24 Tem 2018 ... This phase-solubility technique was first developed by Higuchi and Connors. ... complex formation solubility, spectral and kinetic techniques. J ...Solubility diagrams were obtained according to Higuchi and Connors. 11 . Excess ... Phase solubility techniques, in: C. Reilly (Ed.), Advances in. Analytical ...Phase-solubility analysis Phase-solubility studies were performed using the method described by Higuchi and Connors [17]. A fixed amount of IDE exceeding its solubility, was added to unbuffered aqueous solutions of SBE-b-CD, (0.0–9.0 9 10-3 M) in 10 mL capped tubes, then sonicated in a Bandelin RK 514 water bath (Berlin, Germany) for 15 …HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...The elimina- tion half-life was estimated graphically from the terminal linear phase of the plasma concentra- tion-time curve. Results and Discussion The phase solubility diagram shown in Fig. 1 can be classified as type Bs according to Higuchi and Connors (1965). An insoluble microcrystalline complex was formed in solution at high CD ...Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ...Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...where [D/CD] is the concentration of dissolved drug-cyclodextrin complex, [CD] is the concentration of dissolved free cyclodextrin and slope is the slope of the phase solubility profile (Higuchi, Connors, 1965 Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and Instrumentation.T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117-212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135-149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...Abstract. The effect of polymers and various drugs on the solubility of β-cyclodextrin (βCD) was determined. The apparent stability constant (Kc) of the drug-βCD complex was calculated from the phase-solubility diagrams. The water solubility of βCD was determined to be 1.9% (w/v), but addition of 0.25-1% (w/v) of polyvinylpyrrolidone (PVP ...Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …The phase solubility diagram for complex formation between HC and HPβCD is presented in Fig. 1.The plot shows a typical A L-type solubility curve classified by Higuchi and Connors (1965).The solubility of HC (<0.07 mg/ml) increased in a linear fashion as a function of HPβCD concentration.In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...At 298.2–318.2 K and 101.1 kPa, the solubility of FBX in several mono solvents was measured using an experimental approach proposed by “Higuchi and Connors” . The extra FBX was mixed with the known amount of each mono solvent. The obtained suspensions were vortexed for 10 min.Phase solubility studies. Phase solubility studies were carried out as described by Higuchi & Connors (Higuchi & Connors, 1965). Excess amount of caffeic acid was added to vials containing both CD and ethanol. The concentration of CD varied from 0 to 10 mM and the percentage of ethanol from 0 to 45% v/v.The phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.According to the classification method of Higuchi and Connors (Chen et al., Citation 2007; Higuchi & Connors, Citation 1965), ... Phase-solubility techniques. Adv Chem Instrum 4:117–212 [Google Scholar] Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet.The equilibrium solubility is based on the phase-solubility technique proposed by Higuchi-Connors. Method Drug dispersed in solvent in a closed container ...Feb 5, 2008 · Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations. According to the Higuchi and Connors classification [6], tTo determine binding constants by Higuchi and Connors metho To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug... Solubility diagrams were obtained according to Higuchi and Phase solubility analysis was performed according to the method reported by Higuchi and Conners . An excess amount of RIF was added into a glass vial containing 1 mL of PBS solution (pH = 7.4) with various concentrations of ACB (0, 20, 40, 60, 80, 100 mM, respectively). ... Higuchi, T., Connors, K.A.: Phase-solubility techniques. Adv. …Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, … T. Higuchi and K. A. Connors. Phase solubility techni...

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In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubi...

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[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-1...

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The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase ...

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Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this articl...

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Phase solubility studies The apparent stability constants (K s ) were calculated according to the equations established by ...

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